Micro-tracker

Localising Cytology - placing the objective results from cytological analysis in to histology for greater understanding

 

 

 

 

 

 

 

 

 

 

 

Background
Traditionally the accuracy of results obtained from the cytological analysis of specimens has been separated from the histological review process common in pathology. It has been possible to visually review specimens and obtain objective cytological results of them, but not to view the objective cytology results in context.

The visualisation of accurate objective results from cytology in place within the context of the
histology section will provide both a valuable research tool and will provide increased understanding
of the mechanisms of tumour progression and lead to future clinical tests. The usefulness of the results is certainly expected to be greater than the sum of the two independent analysis methods.

Benefits
• Localised cytology results in a histology context

• Increased understanding of the meaning of the cytological analysis methods

• A valuable research tool in a previously inaccessible scientific area

Scientific Background
The results from advantages of cytolological review of specimens are provided in the explanation of DNA Ploidy. Little is know of the correlation of the cytological results and their spatial location within the tumour as seen on a standard histological glass slide.

Technology
The specimen on the glass slide needs to be imaged, using both slide scanning systems and a high quality microscope. The standard H&E prepared slides have to be scanned using the slide scanning system. The microscope is used to capture images that are used for the analysis of the cytological preparations. Our software then performs the analysis of the cytological images and locates the results obtained back in to the histological scanned images.

All the required hardware to complete the development of the system is currently available. The software systems required performing the analysis and their localisation is Room4’s offering.

Room4  has a patent pending for this method and the practical method to complete it.