Papers published using PWS Software

1. Comparison of nuclear texture analysis and image
cytometric DNA analysis for the assessment of dysplasia
in Barrett’s oesophagus.
Dunn J.M, Hveem T, Pretorius M, Oukrif D, Nielsen B,
Albregtsen F, Lovat L.B, Novelli M.R, Danielsen H. E
British Journal of Cancer, 105(8):1218-23, 2011.

2.DNA ploidy may be a prognostic marker in stage I
and II serous adenocarcinoma of the endometrium
Manohar Pradhan & Ben Davidson & Vera Maria Abeler &
Håvard Emil Danielsen & Claes Göran Tropé &
Gunnar Balle Kristensen & Björn Åke Risberg
Virchows Arch
DOI 10.1007/s00428-012-1275-2.2012

3.Use of multivariate analysis to suggest a new molecular
classification of colorectal cancer.
Enric Domingo,Rajarajan Ramamoorthy,Dahmane Oukrif,Daniel Rosmarin,Michal Presz,Haitao Wang,4Hannah Pulker,Helen Lockstone,Tarjei Hveem,Treena Cranston,Havard Danielsen,Marco Novelli,
Brian Davidson,Zheng-Zhou Xu,Peter Molloy,Elaine Johnstone,Christopher Holmes,Rachel Midgley,
David Kerr,Oliver Sieber, Ian Tomlinson
Journal of Pathology
J Pathol 2013; 229: 441–448

4. Prognostic importance of DNA ploidy and DNA index in
stage I and II endometrioid adenocarcinoma of the
endometrium.
M. Pradhan, V. M. Abeler, H. E. Danielsen, B. Sandstad, C. G. Trope´
G. B. Kristensen & B. A . Risberg
Annals of Oncology 23: 1178–1184, 2012
doi:10.1093/annonc/mdr368
Published online 30 September 2011

Papers published using predecessors of the PWS Software

1. A method for determining ploidy distributions in liver
tissue by stereological analysis of nuclear size calibrated
by flow cytometric DNA analysis.
Danielsen H, Lindmo T, Reith A.
Cytometry 1986; 7(5):475-480.


2. Ploidy distribution in experimental liver carcinogenesis
in mice.
Danielsen HE, Steen HB, Lindmo T, Reith A.
Carcinogenesis 1988; 9(1):59-63.


3. Determination of nuclear DNA content in gynaecological
cancer by image cytometry.
Kaern J, Danielsen HE, Farrants G, Juhng SW, Stenersen
TC, Wetteland J et al.
In: Burger GOMaVGP, editor. Advances in analytical cellular 
pathology. 1990: 17-19.


4. Analytical methods for the study of liver cell proliferation.
Gerlyng P, Stokke T, Huitfeldt HS, Stenersen T, Danielsen
HE, Grotmol T et al.
Cytometry 1992; 13(4):404-415.


5. Comparison between fl ow cytometry and image cytometry
in ploidy distribution assessments in gynecologic
cancer.
Kaern J, Wetteland J, Trope CG, Farrants GW, Juhng SW,
Pettersen EO et al.
Cytometry 1992; 13(3):314-321.


6. Caveats in the estimation of DNA-ploidy in paraffi n
embedded specimens of primary prostate cancer and
lymph node metastases by fl ow and image cytometry.
Berner A, Danielsen HE, Juul NO, Juul ME, Pettersen EO,
Reith A et al.
Analytical Cellular Pathology 1993; 5(6):339-352.


7. DNA distribution in the prostate. Normal gland, benign
and premalignant lesions, and subsequent adenocarcinomas.
Berner A, Danielsen HE, Pettersen EO, Fossa SD, Reith A,
Nesland JM.
Analytical & Quantitative Cytology & Histology 1993;
15(4):247-252.


8. Assessment of DNA ploidy in tumor material: Preparation
and measurement by image cytometry.
Reith A, Danielsen HE.
In: Wied GLeale, editor. Compendium on the computerized
cytology and histology laboratory. 1994: 185-193.


9. Caveats in the use of archival cell material for DNA
ploidy analysis by image cytometry.
Stenersen TC, Danielsen H, Farrants G, Reith A.
Analytical Cellular Pathology 1994; 7(3):217-233.


10. DNA ploidy in laryngeal displastic epithelium and the
ensuing carcinomatous lesions.
Stenersen TC, Danielsen HE, Farrants G, Boysen M, Fraas
Clausen OP, Reith A.
Apmis . 1994.


11. DNA ploidy, serum prostate specifi c antigen, histological
grade and immunohistochemistry as predictive
parameters of lymph node metastases in T1-T3/M0
prostatic adenocarcinoma.
Berner A, Waere H, Nesland JM, Paus E, Danielsen HE,
Fossa SD.
Br J Urol 1995; 75(1):26-32.


12. Histopathological grading and DNA ploidy as prognostic
markers in metastatic prostatic cancer.
Jorgensen T, Yogesan K, Skjorten F, Berner A, Tveter KJ,
Danielsen HE.
Br J Cancer 1995; 71(5):1055-1060.


13. Histopathological grading and DNA ploidy as prognostic
markers in metastatic prostate cancer.
Jørgensen T, Yogesan K, Skjørten F, Berner A, Tveter KJ,
Danielsen HE.
British Journal of Cancer 71, 1055-1060. 1995.


14. The prognosis signifi cance of the DNA ploidy pattern of
severe dysplasia and carcinoma in situ of the larynx.
Stenersen TC, Danielsen HE, Farrants G, Boysen M, Fraas
Claussen OP, Reith A.
Cancer. 1995.


15. Prognostic factors in patients with metastatic (stage
D2) prostate cancer: experience from the Scandinavian
Prostatic Cancer Group Study-2.
Jorgensen T, Kanagasingam Y, Kaalhus O, Tveter KJ, Bryne
M, Skjorten F et al.
J Urol 1997; 158(1):164-170.


16. Synovial sarcoma. Evaluation of prognosis with
emphasis on the study of DNA ploidy and proliferation
(PCNA and Ki-67) markers.
Lopes JM, Hannisdal E, Bjerkehagen B, Bruland OS,
Danielsen HE, Pettersen EO et al.
Analytical Cellular Pathology 1998; 16(1):45-62.


17. TP53 and p21 WAF1/CIP1 behave differently in euploid
vs. Aneuploid bladder tumours treated with radiotherapy.
R. Røtterud, H. Skomedal, Aa Berner, H.E. Danielsen, , E
Skovlund and S.D. Fosså
Acta Oncologica 2001; 40(5):644-652.


18. Fourth updated ESACP consensus report on diagnostic
DNA image Cytometry.
G. Haroske, J.P. Baak, H. Danielsen, F. Giroud, A.
Geschwendtner, M. Oberholzer, A. Reith, P. Spieler, A.
Bocking.
Anal. Cell. Pathol., 2001; 23(2): 89-95.


19. Large-scale genomic instability predicts long-term
outcome of women with early ovarian cancer.
G.B. Kristensen, W. Kildal, V.M. Abeler, E.O. Pettersen, C.
Trope, H.E. Danielsen
Annals of Oncology 14(10):1494-1500, 2003


20. Genome profi les of bilateral dysgerminomas, a unilateral
gonadoblastoma, and a metastasis from a 46, XY
phenotypic female
W. Kildal, S. M. Kaggerud, V.M. Abeler, S. Heim, C. G.
Tropé, G.B.Kristensen, B. Risberg, R.A. Lothe and H. E.
Danielsen
Human Pathology: 34(9); 946-949, 2003.


21. TP53 mutations in early stage ovarian carcinoma,
relation to long-term survival.
Y. Wang, Å. Helland, R. Holm, H. Skomedal, V.M. Abeler,
H.E. Danielsen, C.G. Trope, A-L. Børresen, G. B. Kristensen.
British Journal of Cancer, 90(3):678-685, 2004


22. Pilomatrix carcinoma with lymph node metastases.
Bassarova A, Nesland JM, Sedloev T, Danielsen H,
Christova S.
Journal of cutaneous pathology, 31(4):330-335, 2004


23. Evaluation of genomic changes in a large series of
malignant ovarian germ cell tumors – relation to
clinicopathological variables.
Wanja Kildal, Janne Kærn, Sigrid Marie Kraggerud, Vera
M. Abeler, Jon Sudbø, Claes G. Tropè, Ragnhild A. Lothe
and Håvard E. Danielsen
Cancer Genetics and Cytogenetics, 155(1):25-32, 2004.

24. B-catenin expression, DNA ploidy and clinicopathological
features in 253 women with ovarian carcinoma.
Wanja Kildal, Bjørn Risberg, Vera M. Abeler, Gunnar B.
Kristensen, Jon Sudbø, Jahn M. Nesland and Håvard E.
Danielsen.
Eur J Cancer 41(8);1127-1134, 2005.

25. Prognostic factors in ovarian carcinoma stage III
patients. Can biomarkers improve the prediction of
short- and long-term survivors?
Kaern, J., Aghmesheh, M., Nesland, J.M., Danielsen, H.E.,
Sandstad, B., Friedlander, M. & Trope, C.
Int J Gynecol Cancer 15:1-9, 2005.


26. Genomic aberrations in mucinous tubular and spindle
cell renal cell carcinomas.
Petter Brandal, Agnes Kathrine Lie, Assia Bassarova, Aud
Svinland, Bjørn Risberg, Håvard E. Danielsen and Sverre
Heim
Mod Pathol. 19(2): 186-194, 2006.


27. Image cytometry DNA ploidy correlates with histological
subtypes in endometrial carcinomas.
M. Pradhan, V.M. Abeler, H.E. Danielsen, C.G. Trope and B.
Risberg
Mod Pathol. 19(9):1227-35, 2006.


28. A distinct pattern in the DNA ploidy histograms of
hydatidiform moles and nonmolar abortuses is caused
by accumulation of trophoblasts in the late s-phase.
Pradhan M, Abeler VM, Danielsen HE, Risberg B.
Int J Gynecol Pathol. 2007 Oct;26(4):432-6.


29. Consistent numerical chromosome aberrations in
thecofi bromas of the ovary.
Micci F, Haugom L, Abeler VM, Tropé CG, Danielsen HE,
Heim S.
Virchows Arch. 452 (3), 269-76, 2008


30. The prognostic value of DNA ploidy in a total population
of uterine sarcomas.
Kildal W, Abeler VM, Kristensen GB, Jenstad M, Thoresen
SO, Danielsen HE
Ann Oncol. Jun;20(6):1037-41. 2009


31. Gross genomic alterations differ between serous
borderline tumors and serous adenocarcinomas - An
image cytometric DNA ploidy analysis of 307 cases
with histogenetic implications.
Pradhan, Manohar; Davidson, Ben; Tropé, Claes; Danielsen,
Håvard; Abeler, Vera; Risberg, Björn
Virchows Arch. Jun;454(6):677-83. 2009


32. Large Scale Genomic Instability as an Additive Prognostic
Marker in Early Prostate Cancer.
Maria E. Pretorius, Håkon Wæhre, Vera M. Abeler, Ben
Davidson, Ljiljana Vlatkovic, Ragnhild A. Lothe, Karl-Erik
Giercksky and Håvard E. Danielsen.
Cell Oncol.;31(4):251-9. 2009


33. Large-scale genomic instability in colon adenocarcinomas
and correlation with patient outcome.
Bondi J, Pretorius M, Bukholm I, Danielsen H.
APMIS. Oct;117(10):730-6. 2009


34. DNA ploidy heterogeneity in endometrial carcinoma:
comparison between curettage and hysterectomy
specimens.
Pradan M, Abeler VM, Davidson B, Kildal W, Nybøen Å, Trope
CG, Risberg B, Danielsen HE.
Int J Gynecol Pathol., 29(6):572-8, 2010


35. Comparison of nuclear texture analysis and image
cytometric DNA analysis for the assessment of dysplasia
in Barrett’s oesophagus.
Dunn J.M, Hveem T, Pretorius M, Oukrif D, Nielsen B,
Albregtsen F, Lovat L.B, Novelli M.R, Danielsen H. E
British Journal of Cancer, 105(8):1218-23, 2011.


36. Prognostic importance of DNA ploidy and DNA index
in stage I and II endometrioid adenocarcinoma of the
endometrium.
Pradhan M, Abeler VM, Danielsen HE, Sandstad B, Tropé
CG, Kristensen GB and Risberg BÅ.
Ann Oncol 2011. sep 30 ( Epub ahead of print)


37. Multiple chromosomal monosomies are characteristic of
giant-cell ependymoma.
Dahlback H-SS, Brandal P, Krossnes BK, Fric R, Meling TR,
Meza-Zepeda L, Danielsen HE, Heim S.
Hum Pathol. 42(12):2042-2046, 2011.


38. Genomic imbalances in type I endometrial carcinomas –
comparison of DNA ploidy, karyotyping and comparative
genomic hybridization.
Kildal W, Micci F, Risberg B, Abeler VM, Heim S, Danielsen H
Mol Oncol 6(1):98-107, 2012.


39. Large scale genomic instability is a sensitive predictor
for relapse in patients with stage II colon cancer.
Danielsen H. E, Hveem T. S, Pretorius M.E, Clinch N, Merok
M, Sjo O, Liestøl K, Lothe R and Nesbakken A.
1. A method for determining ploidy distributions in liver
tissue by stereological analysis of nuclear size calibrated
by fl ow cytometric DNA analysis.
Danielsen H, Lindmo T, Reith A.
Cytometry 1986; 7(5):475-480.