Publications

Selected peer-reviewed papers that used the Ploidy Work Station (PWS) software and its predecessors.

Papers using the PWS software

  1. Comparison of nuclear texture analysis and image cytometric DNA analysis for the assessment of dysplasia in Barrett’s oesophagus. Dunn J.M, Hveem T, Pretorius M, Oukrif D, Nielsen B, Albregtsen F, Lovat L.B, Novelli M.R, Danielsen H. E British Journal of Cancer, 105(8):1218-23, 2011.
  2. DNA ploidy may be a prognostic marker in stage I and II serous adenocarcinoma of the endometrium Manohar Pradhan & Ben Davidson & Vera Maria Abeler & Håvard Emil Danielsen & Claes Göran Tropé & Gunnar Balle Kristensen & Björn Åke Risberg Virchows Arch DOI 10.1007/s00428-012-1275-2.2012
  3. Use of multivariate analysis to suggest a new molecular classification of colorectal cancer. Enric Domingo,Rajarajan Ramamoorthy,Dahmane Oukrif,Daniel Rosmarin,Michal Presz,Haitao Wang,4Hannah Pulker,Helen Lockstone,Tarjei Hveem,Treena Cranston,Havard Danielsen,Marco Novelli, Brian Davidson,Zheng-Zhou Xu,Peter Molloy,Elaine Johnstone,Christopher Holmes,Rachel Midgley, David Kerr,Oliver Sieber, Ian Tomlinson Journal of Pathology J Pathol 2013; 229: 441–448
  4. Prognostic importance of DNA ploidy and DNA index in stage I and II endometrioid adenocarcinoma of the endometrium. M. Pradhan, V. M. Abeler, H. E. Danielsen, B. Sandstad, C. G. Trope´ G. B. Kristensen & B. A . Risberg Annals of Oncology 23: 1178–1184, 2012 doi:10.1093/annonc/mdr368 Published online 30 September 2011

Papers using predecessors of the PWS software

  1. A method for determining ploidy distributions in liver tissue by stereological analysis of nuclear size calibrated by flow cytometric DNA analysis. Danielsen H, Lindmo T, Reith A. Cytometry 1986; 7(5):475-480.
  2. Ploidy distribution in experimental liver carcinogenesis in mice. Danielsen HE, Steen HB, Lindmo T, Reith A. Carcinogenesis 1988; 9(1):59-63.
  3. Determination of nuclear DNA content in gynaecological cancer by image cytometry. Kaern J, Danielsen HE, Farrants G, Juhng SW, Stenersen TC, Wetteland J et al. In: Burger GOMaVGP, editor. Advances in analytical cellular pathology. 1990: 17-19.
  4. Analytical methods for the study of liver cell proliferation. Gerlyng P, Stokke T, Huitfeldt HS, Stenersen T, Danielsen HE, Grotmol T et al. Cytometry 1992; 13(4):404-415.
  5. Comparison between flow cytometry and image cytometry in ploidy distribution assessments in gynecologic cancer. Kaern J, Wetteland J, Trope CG, Farrants GW, Juhng SW, Pettersen EO et al. Cytometry 1992; 13(3):314-321.
  6. Caveats in the estimation of DNA-ploidy in paraffin embedded specimens of primary prostate cancer and lymph node metastases by flow and image cytometry. Berner A, Danielsen HE, Juul NO, Juul ME, Pettersen EO, Reith A et al. Analytical Cellular Pathology 1993; 5(6):339-352.
  7. DNA distribution in the prostate. Normal gland, benign and premalignant lesions, and subsequent adenocarcinomas. Berner A, Danielsen HE, Pettersen EO, Fossa SD, Reith A, Nesland JM. Analytical & Quantitative Cytology & Histology 1993; 15(4):247-252.
  8. Assessment of DNA ploidy in tumor material: Preparation and measurement by image cytometry. Reith A, Danielsen HE. In: Wied GLeale, editor. Compendium on the computerized cytology and histology laboratory. 1994: 185-193.
  9. Caveats in the use of archival cell material for DNA ploidy analysis by image cytometry. Stenersen TC, Danielsen H, Farrants G, Reith A. Analytical Cellular Pathology 1994; 7(3):217-233.
  10. DNA ploidy in laryngeal displastic epithelium and the ensuing carcinomatous lesions. Stenersen TC, Danielsen HE, Farrants G, Boysen M, Fraas Clausen OP, Reith A. Apmis . 1994.
  11. DNA ploidy, serum prostate specific antigen, histological grade and immunohistochemistry as predictive parameters of lymph node metastases in T1-T3/M0 prostatic adenocarcinoma. Berner A, Waere H, Nesland JM, Paus E, Danielsen HE, Fossa SD. Br J Urol 1995; 75(1):26-32.
  12. Histopathological grading and DNA ploidy as prognostic markers in metastatic prostatic cancer. Jorgensen T, Yogesan K, Skjorten F, Berner A, Tveter KJ, Danielsen HE. Br J Cancer 1995; 71(5):1055-1060.
  13. The prognosis significance of the DNA ploidy pattern of severe dysplasia and carcinoma in situ of the larynx. Stenersen TC, Danielsen HE, Farrants G, Boysen M, Fraas Claussen OP, Reith A. Cancer. 1995.
  14. Prognostic factors in patients with metastatic (stage D2) prostate cancer: experience from the Scandinavian Prostatic Cancer Group Study-2. Jorgensen T, Kanagasingam Y, Kaalhus O, Tveter KJ, Bryne M, Skjorten F et al. J Urol 1997; 158(1):164-170.
  15. Synovial sarcoma. Evaluation of prognosis with emphasis on the study of DNA ploidy and proliferation (PCNA and Ki-67) markers. Lopes JM, Hannisdal E, Bjerkehagen B, Bruland OS, Danielsen HE, Pettersen EO et al. Analytical Cellular Pathology 1998; 16(1):45-62.
  16. TP53 and p21 WAF1/CIP1 behave differently in euploid vs. Aneuploid bladder tumours treated with radiotherapy. R. Røtterud, H. Skomedal, Aa Berner, H.E. Danielsen, , E Skovlund and S.D. Fosså Acta Oncologica 2001; 40(5):644-652.
  17. Fourth updated ESACP consensus report on diagnostic DNA image Cytometry. G. Haroske, J.P. Baak, H. Danielsen, F. Giroud, A. Geschwendtner, M. Oberholzer, A. Reith, P. Spieler, A. Bocking. Anal. Cell. Pathol., 2001; 23(2): 89-95.
  18. Large-scale genomic instability predicts long-term outcome of women with early ovarian cancer. G.B. Kristensen, W. Kildal, V.M. Abeler, E.O. Pettersen, C. Trope, H.E. Danielsen Annals of Oncology 14(10):1494-1500, 2003
  19. Genome profiles of bilateral dysgerminomas, a unilateral gonadoblastoma, and a metastasis from a 46, XY phenotypic female W. Kildal, S. M. Kaggerud, V.M. Abeler, S. Heim, C. G. Tropé, G.B.Kristensen, B. Risberg, R.A. Lothe and H. E. Danielsen Human Pathology: 34(9); 946-949, 2003.
  20. TP53 mutations in early stage ovarian carcinoma, relation to long-term survival. Y. Wang, Å. Helland, R. Holm, H. Skomedal, V.M. Abeler, H.E. Danielsen, C.G. Trope, A-L. Børresen, G. B. Kristensen. British Journal of Cancer, 90(3):678-685, 2004
  21. Pilomatrix carcinoma with lymph node metastases. Bassarova A, Nesland JM, Sedloev T, Danielsen H, Christova S. Journal of cutaneous pathology, 31(4):330-335, 2004
  22. Evaluation of genomic changes in a large series of malignant ovarian germ cell tumors – relation to clinicopathological variables. Wanja Kildal, Janne Kærn, Sigrid Marie Kraggerud, Vera M. Abeler, Jon Sudbø, Claes G. Tropè, Ragnhild A. Lothe and Håvard E. Danielsen Cancer Genetics and Cytogenetics, 155(1):25-32, 2004.
  23. B-catenin expression, DNA ploidy and clinicopathological features in 253 women with ovarian carcinoma. Wanja Kildal, Bjørn Risberg, Vera M. Abeler, Gunnar B. Kristensen, Jon Sudbø, Jahn M. Nesland and Håvard E. Danielsen. Eur J Cancer 41(8);1127-1134, 2005.
  24. Prognostic factors in ovarian carcinoma stage III patients. Can biomarkers improve the prediction of short- and long-term survivors? Kaern, J., Aghmesheh, M., Nesland, J.M., Danielsen, H.E., Sandstad, B., Friedlander, M. & Trope, C. Int J Gynecol Cancer 15:1-9, 2005.
  25. Genomic aberrations in mucinous tubular and spindle cell renal cell carcinomas. Petter Brandal, Agnes Kathrine Lie, Assia Bassarova, Aud Svinland, Bjørn Risberg, Håvard E. Danielsen and Sverre Heim Mod Pathol. 19(2): 186-194, 2006.
  26. Image cytometry DNA ploidy correlates with histological subtypes in endometrial carcinomas. M. Pradhan, V.M. Abeler, H.E. Danielsen, C.G. Trope and B. Risberg Mod Pathol. 19(9):1227-35, 2006.
  27. A distinct pattern in the DNA ploidy histograms of hydatidiform moles and nonmolar abortuses is caused by accumulation of trophoblasts in the late s-phase. Pradhan M, Abeler VM, Danielsen HE, Risberg B. Int J Gynecol Pathol. 2007 Oct;26(4):432-6.
  28. Consistent numerical chromosome aberrations in thecofibromas of the ovary. Micci F, Haugom L, Abeler VM, Tropé CG, Danielsen HE, Heim S. Virchows Arch. 452 (3), 269-76, 2008
  29. The prognostic value of DNA ploidy in a total population of uterine sarcomas. Kildal W, Abeler VM, Kristensen GB, Jenstad M, Thoresen SO, Danielsen HE Ann Oncol. Jun;20(6):1037-41. 2009
  30. Gross genomic alterations differ between serous borderline tumors and serous adenocarcinomas - An image cytometric DNA ploidy analysis of 307 cases with histogenetic implications. Pradhan, Manohar; Davidson, Ben; Tropé, Claes; Danielsen, Håvard; Abeler, Vera; Risberg, Björn Virchows Arch. Jun;454(6):677-83. 2009
  31. Large Scale Genomic Instability as an Additive Prognostic Marker in Early Prostate Cancer. Maria E. Pretorius, Håkon Wæhre, Vera M. Abeler, Ben Davidson, Ljiljana Vlatkovic, Ragnhild A. Lothe, Karl-Erik Giercksky and Håvard E. Danielsen. Cell Oncol.;31(4):251-9. 2009
  32. Large-scale genomic instability in colon adenocarcinomas and correlation with patient outcome. Bondi J, Pretorius M, Bukholm I, Danielsen H. APMIS. Oct;117(10):730-6. 2009
  33. DNA ploidy heterogeneity in endometrial carcinoma: comparison between curettage and hysterectomy specimens. Pradan M, Abeler VM, Davidson B, Kildal W, Nybøen Å, Trope CG, Risberg B, Danielsen HE. Int J Gynecol Pathol., 29(6):572-8, 2010
  34. Multiple chromosomal monosomies are characteristic of giant-cell ependymoma. Dahlback H-SS, Brandal P, Krossnes BK, Fric R, Meling TR, Meza-Zepeda L, Danielsen HE, Heim S. Hum Pathol. 42(12):2042-2046, 2011.
  35. Genomic imbalances in type I endometrial carcinomas – comparison of DNA ploidy, karyotyping and comparative genomic hybridization. Kildal W, Micci F, Risberg B, Abeler VM, Heim S, Danielsen H Mol Oncol 6(1):98-107, 2012.
  36. Large scale genomic instability is a sensitive predictor for relapse in patients with stage II colon cancer. Danielsen H. E, Hveem T. S, Pretorius M.E, Clinch N, Merok M, Sjo O, Liestøl K, Lothe R and Nesbakken A.